解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The native microflora associated with mosquitoes have important roles in mosquito development and vector competence. Sequencing of bacterial V3 region from 16S rRNA genes across the developmental stages of Culex mosquitoes (early and late larval instars, pupae and adults) was used to test the hypothesis that...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0475-8
更新日期:2015-07-24 00:00:00
abstract:BACKGROUND:In the genome of H. pylori 26695, 149 proteins containing the CXXC motif characteristic of thioldisulfide oxidoreductases have been identified to date. However, only two of these proteins have a thioredoxin-like fold (i.e., HP0377 and HP0231) and are periplasm-located. We have previously shown that HP0231 is...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0471-z
更新日期:2015-07-04 00:00:00
abstract:BACKGROUND:Cryptosporidium spp. and Giardia duodenalis are important causes of diarrheal diseases in humans and animals worldwide, and there is an increased interest in the role of animals in the mechanical transmission of these protozoa. To examine the role of yaks in this process, we examined the occurrence and genot...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0446-0
更新日期:2015-05-21 00:00:00
abstract:BACKGROUND:Legionella testing conducted at environmental laboratories plays an essential role in assessing the risk of disease transmission associated with water systems. However, drawbacks of culture-based methodology used for Legionella enumeration can have great impact on the results and interpretation which togethe...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0423-7
更新日期:2015-04-29 00:00:00
abstract:BACKGROUND:Xanthophyllomyces dendrorhous is a basidiomycetous yeast that synthesizes astaxanthin, a carotenoid with great biotechnological impact. The ergosterol and carotenoid synthetic pathways derive from the mevalonate pathway and involve cytochrome P450 enzymes. Among these enzymes, the CYP51 family, which is invo...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0428-2
更新日期:2015-04-25 00:00:00
abstract:BACKGROUND:The date palm root borer Oryctes agamemnon (Coleoptera: Scarabaeidae) is one of the major pests of palms. In Saudi Arabia, both larvae and adults of Oryctes are particularly troublesome, especially during the establishment of young date palm orchards. Endosymbiotic bacteria are known to have a key role in fo...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0422-8
更新日期:2015-04-22 00:00:00
abstract:BACKGROUND:Saudi Arabia is mostly barren except the southwestern highlands that are susceptible to environmental changes, a hotspot for biodiversity, but poorly studied for microbial diversity and composition. In this study, 454-pyrosequencing of 16S rRNA gene hypervariable region V6 was used to analyze soil bacterial ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0398-4
更新日期:2015-03-14 00:00:00
abstract:BACKGROUND:Candida albicans yeast produces 10 distinct secreted aspartic proteases (Saps), which are some of the most important virulence factors of this pathogenic fungus. One of the suggested roles of Saps is their deregulating effect on various proteolytic cascades that constitute the major homeostatic systems in hu...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0394-8
更新日期:2015-03-04 00:00:00
abstract:BACKGROUND:The infections caused by antibiotic multidrug-resistant bacteria seriously threaten human health. To prevent and cure the infections caused by multidrug-resistant bacteria, new antimicrobial agents are required. Antimicrobial peptides are ideal therapy candidates for antibiotic-resistant pathogens. However, ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0389-5
更新日期:2015-03-03 00:00:00
abstract:BACKGROUND:Viability staining with SYTO9 and propidium iodide (PI) is a frequently used tool in microbiological studies. However, data generated by such routinely used method are often not critically evaluated for their accuracy. In this study we aim to investigate the critical aspects of this staining method using Sta...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0376-x
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:Microorganisms of different species interact in several ecological niches, even causing infection. During the infectious process, a biofilm of single or multispecies can develop. Aspergillus fumigatus and Staphyloccocus aureus are etiologic agents that can cause infectious keratitis. We analyzed in vitro sin...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0363-2
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Participation of renal cells in the pathogenesis of staphylococcal enterotoxin B (SEB) is critical for late cleansing and sequestration of the antigens facilitated by CD1d mediated antigen sensing and recognition. This is a noted deviation from the typical antigen recognition process that recruits the major ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0344-5
更新日期:2015-02-04 00:00:00
abstract:BACKGROUND:Bifidobacteria is one of the major gut commensal groups found in infants. Their colonization is commonly associated with beneficial effects to the host through mechanisms like niche occupation and nutrient competition against pathogenic bacteria. Iron is an essential element necessary for most microorganisms...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0334-z
更新日期:2015-01-16 00:00:00
abstract:BACKGROUND:For a good probiotic candidate, the abilities to adhere to intestinal epithelium and to fortify barrier function are considered to be crucial for colonization and functionality of the strain. The strain Lactobacillus acidophilus LAB20 was isolated from the jejunum of a healthy dog, where it was found to be t...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0337-9
更新日期:2015-01-16 00:00:00
abstract:BACKGROUND:Biofilm formation by Candida albicans has shown to be highly variable and is directly associated with pathogenicity and poor clinical outcomes in patients at risk. The aim of this study was to test the hypotheses that the extracellular DNA release by C. albicans is strain dependent and is associated with bio...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0303-6
更新日期:2014-12-05 00:00:00
abstract:BACKGROUND:Papua New Guinea (PNG) is a high tuberculosis (TB) burden country of the WHO Western Pacific Region, but so far research on drug resistance (DR) and genotypes of Mycobacterium tuberculosis (M. tuberculosis) was only conducted in few provinces in the country. The aim of the present study was to obtain baselin...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0307-2
更新日期:2014-12-05 00:00:00
abstract:BACKGROUND:Pseudomonas syringae is pathogenic to a large number of plant species. For host colonization and disease progression, strains of this bacterium utilize an array of type III-secreted effectors and other virulence factors, including small secreted molecules such as syringolin A, a peptide derivative that inhib...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0304-5
更新日期:2014-12-04 00:00:00
abstract:BACKGROUND:Pseudomonas fuscovaginae (Pfv) is an emerging plant pathogen of rice and also of other gramineae plants. It causes sheath brown rot disease in rice with symptoms that are characterized by brown lesions on the flag leaf sheath, grain discoloration and sterility. It was first isolated as a high altitude pathog...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0274-7
更新日期:2014-11-14 00:00:00
abstract:BACKGROUND:Botrytis cinerea secretes a high number of proteins that are predicted to have numerous O-glycosylation sites, frequently grouped in highly O-glycosylated regions, and analysis of mutants affected in O-glycosylation has shown, in B. cinerea and in other phytopathogenic fungi, that this process is important f...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0254-y
更新日期:2014-10-12 00:00:00
abstract:BACKGROUND:Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negative facultative intracellular bacteria that are responsible for brucellosis, a worldwide extended ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0223-5
更新日期:2014-09-02 00:00:00
abstract:BACKGROUND:Staphylococcus aureus (S. aureus) is one of the primary causes of bone infections which are often chronic and difficult to eradicate. Bacteria like S. aureus may survive upon internalization in cells and may be responsible for chronic and recurrent infections. In this study, we compared the responses of a ph...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0207-5
更新日期:2014-07-25 00:00:00
abstract:BACKGROUND:Meiotic cells undergo two rounds of nuclear division and generate gametes. Previous studies have indicated that a number of transcription factors modulate the transcriptome in successive waves during meiosis and spore formation in fission yeast. However, the mechanisms underlying the post-transcriptional reg...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-188
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:The microbiota of the mammalian gastrointestinal (GI) tract consists of diverse populations of commensal bacteria that interact with host physiological function. Dysregulating these populations, through exogenous means such as antibiotics or dietary changes, can have adverse consequences on the health of the...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-189
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:The Gram-negative bacterium Erwinia amylovora is the causal agent of the devastating disease fire blight in rosaceous plants such as apple, pear, quince, raspberry, and cotoneaster. In order to survive and multiply in a host, microbes must be able to circumvent the toxic effects of antimicrobial plant compou...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-185
更新日期:2014-07-11 00:00:00
abstract:BACKGROUND:Brucellosis caused by Brucella abortus is one of the most important zoonoses in the world. Multiple-locus variable-number tandem repeat analysis (MLVA16) has been shown be a useful tool to epidemiological traceback studies in B. abortus infection. Thus, the present study aimed (i) to evaluate the genetic div...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-186
更新日期:2014-07-11 00:00:00
abstract:BACKGROUND:Flavobacterium columnare (Bacteroidetes) is the causative agent of columnaris disease in farmed freshwater fish around the world. The bacterium forms three colony morphotypes (Rhizoid, Rough and Soft), but the differences of the morphotypes are poorly known. We studied the virulence of the morphotypes produc...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-170
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:Bacterial lipoproteins often play important roles in pathogenesis and can stimulate protective immune responses. Such lipoproteins are viable vaccine candidates. Haemophilus ducreyi, which causes the sexually transmitted disease chancroid, expresses a number of lipoproteins during human infection. One such l...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-166
更新日期:2014-06-24 00:00:00
abstract:BACKGROUND:The ColRS two-component system has been shown to contribute to the membrane functionality and stress tolerance of Pseudomonas putida as well as to the virulence of Pseudomonas aeruginosa and plant pathogenic Xanthomonas species. However, the conditions activating the ColRS pathway and the signal(s) sensed by...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-162
更新日期:2014-06-20 00:00:00
abstract:BACKGROUND:During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated. RESULTS:The isolates exhibited the same PFGE profile and a mul...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-148
更新日期:2014-06-07 00:00:00
abstract:BACKGROUND:Multi-locus sequence typing (MLST) is a portable, broadly applicable method for classifying bacterial isolates at an intra-species level. This methodology provides clinical and scientific investigators with a standardized means of monitoring evolution within bacterial populations. MLST uses the DNA sequences...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-143
更新日期:2014-06-03 00:00:00
abstract:BACKGROUND:Recent scientific developments have shed more light on the importance of the host-microbe interaction, particularly in the gut. However, the mechanistic study of the host-microbe interplay is complicated by the intrinsic limitations in reaching the different areas of the gastrointestinal tract (GIT) in vivo....
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-133
更新日期:2014-05-22 00:00:00
abstract:BACKGROUND:The genus Phytophthora includes a group of agriculturally important pathogens and they are commonly regarded as water molds. They produce motile zoospores that can move via water currents and on their own locomotion in aquatic environments. However, zoosporic response to dissolved oxygen, an important water ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-124
更新日期:2014-05-13 00:00:00
abstract:BACKGROUND:Nitric oxide (NO) is produced as part of the host immune response to bacterial infections, including urinary tract infections. The enzyme flavohemoglobin, coded by the hmp gene, is involved in protecting bacterial cells from the toxic effects of NO and represents a potentially interesting target for developm...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-65
更新日期:2014-03-14 00:00:00
abstract:BACKGROUND:Enterococci, ubiquitous colonizers of humans and other animals, play an increasingly important role in health-care associated infections (HAIs). It is believed that the recent evolution of two clinically relevant species, Enterococcus faecalis and Enterococcus faecium occurred in a big part in a hospital env...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-66
更新日期:2014-03-14 00:00:00
abstract:BACKGROUND:Successful viral infection requires the involvement of host cellular factors in their life cycle. Heat shock protein 70 (HSP70) can be recruited by numerous viruses to promote the folding, maturation, or assembly of viral proteins. We have previously shown that HSP70 is significantly elevated in porcine repr...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-64
更新日期:2014-03-13 00:00:00
abstract:BACKGROUND:Rhodosporidium toruloides is a β-carotenoid accumulating, oleaginous yeast that has great biotechnological potential. The lack of reliable and efficient genetic manipulation tools have been a major hurdle blocking its adoption as a biotechnology platform. RESULTS:We report for the first time the development...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-50
更新日期:2014-02-27 00:00:00
abstract:BACKGROUND:A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discove...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-2
更新日期:2014-01-02 00:00:00
abstract:BACKGROUND:Adenosine triphosphate (ATP) is used as an intracellular energy source by all living organisms. It plays a central role in the respiration and metabolism, and is the most important energy supplier in many enzymatic reactions. Its critical role as the energy storage molecule makes it extremely valuable to all...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-301
更新日期:2013-12-24 00:00:00
abstract:BACKGROUND:Streptococcus agalactiae or Group B Streptococci (GBS) have the ability to access various host sites, which reflects its adaptability to different environments during the course of infection. This adaptation is due to the expression of virulence factors that are involved with survival, invasion and bacterial...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-297
更新日期:2013-12-21 00:00:00
abstract:BACKGROUND:The environment is the likely source of many pathogenic mycobacterial species but detection of mycobacteria by bacteriological tools is generally difficult and time-consuming. Consequently, several molecular targets based on the sequences of housekeeping genes, non-functional RNA and structural ribosomal RNA...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-277
更新日期:2013-12-03 00:00:00